Through games of Sunday, Dec. 5, 2021:
| # | School (No. 1 votes) | W-L | Pts. | Prev. |
| 1 | Yeshiva (13) | 10-0 | 603 | 1 |
| 2 | Randolph-Macon (8) | 8-1 | 591 | 3 |
| 3 | Illinois Wesleyan (3) | 7-0 | 590 | 2 |
| 4 | UW-Platteville (1) | 9-0 | 563 | 4 |
| 5 | St. Joseph (Conn.) | 6-0 | 487 | 6 |
| 6 | UW-Oshkosh | 8-1 | 479 | 10 |
| 7 | Elmhurst | 7-1 | 395 | 7 |
| 8 | Wheaton (Ill.) | 7-1 | 388 | 5 |
| 9 | Mary Hardin-Baylor | 4-0 | 379 | 11 |
| 10 | Marietta | 4-2 | 357 | 13 |
| 11 | Roanoke | 6-1 | 356 | 9 |
| 12 | Johns Hopkins | 7-1 | 320 | 15 |
| 13 | UW-La Crosse | 7-2 | 310 | 8 |
| 14 | Christopher Newport | 6-2 | 300 | 17 |
| 15 | Whitworth | 6-1 | 276 | 16 |
| 16 | Trine | 5-1 | 229 | 14 |
| 17 | Mount Union | 5-1 | 218 | 12 |
| 18 | Washington U. | 7-1 | 205 | 20 |
| 19 | Swarthmore | 6-1 | 197 | 18 |
| 20 | Williams | 7-0 | 164 | -- |
| 21 | Amherst | 7-0 | 121 | 21 |
| 22 | RPI | 6-0 | 106 | 23 |
| 23 | Emory | 4-2 | 103 | 22 |
| 24 | Maryville (Tenn.) | 6-1 | 58 | 24 |
| 25 | DeSales | 8-0 | 51 | 25 |
Dropped out: No. 19 Wesleyan.
Others receiving votes: Wesleyan (Conn.) 46; Lynchburg 38; WPI 37; Calvin 24; Case Western Reserve 19; Wooster 14; Widener 11; Oswego 10; Cal Lutheran 10; Mass-Dartmouth 10; Heidelberg 9; Berry 8; Colby 6; Hardin-Simmons 6; Trinity (Texas) 6; LeTourneau 4; Rochester 5; Brandeis 4; Nazareth 2; Wartburg 2; Hanover 1; Mary Washington 1; Nichols 1; Stockton 1.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly. Points are awarded on a 25-24-23-22-etc. basis.