Through games of Jan. 22, 2006:
| # | Team | W-L | Pts. | Last Week |
| 1 | Southern Maine (21) | 16-1 | 619 | 1 |
| 2 | Scranton (2) | 16-1 | 593 | 3 |
| 3 | Washington U. | 14-2 | 510 | 2 |
| 4 | Mary Washington (2) | 16-0 | 505 | 5 |
| 5 | DePauw | 17-1 | 492 | 10 |
| 6 | Bowdoin | 13-2 | 471 | 8 |
| 7 | Hope | 16-1 | 465 | 11 |
| 8 | Baldwin-Wallace | 15-2 | 395 | 12 |
| 9 | New York University | 15-1 | 382 | 18 |
| 10 | Messiah | 16-1 | 379 | 13 |
| 11 | Wheaton (Ill.) | 14-2 | 360 | 6 |
| 12 | Brandeis | 12-2 | 350 | 7 |
| 13 | McMurry | 16-0 | 344 | 14 |
| 14 | George Fox | 15-2 | 321 | 4 |
| 15 | Randolph-Macon | 13-2 | 293 | 15 |
| 16 | Capital | 15-2 | 286 | 9 |
| 17 | Salem State | 13-1 | 259 | 19 |
| 18 | Calvin | 14-2 | 224 | 17 |
| 19 | Mississippi College | 13-1 | 133 | 22 |
| 20 | Hardin-Simmons | 13-2 | 130 | 23 |
| 21 | Pacific Lutheran | 14-2 | 103 | 25 |
| 22 | Trinity (Texas) | 14-2 | 77 | — |
| 23 | Rochester | 13-3 | 66 | — |
| 24 | Chicago | 13-3 | 57 | 20 |
| 25 | Wilmington | 12-5 | 43 | — |
Dropped out: No. 16 Moravian; No. 21 Richard Stockton; No. 24 UW-La Crosse
Others receiving votes: Washington and Jefferson 41, Moravian 38, Muhlenberg 30, UW-Oshkosh 29, Lawrence 29, Luther 22, Williams 20, Bates 15, Simpson 13, Carroll 8, UW-La Crosse 6, Oglethorpe 6, Richard Stockton 3, UW-Stevens Point 3, Catholic 2, Mount St. Mary 1.
The D3hoops.com Top 25 is voted on by a panel of 25 coaches, Sports Information Directors and media members from across the country, and is published weekly.